Move
the way
you
want to.
Looking after your joints isn’t about slowing down.
It’s about being in control of your movement, giving you the confidence that every step is supported by a joint health supplement ingredient made for healthy people.
Say hello to UC-II® collagen.
Shop partner productsBuild joint support into your healthy routine
Movement means something different to everyone, whether it’s training harder, staying active for longer, or simply feeling more comfortable every day. Looking after your joints can help you keep moving the way you want to with trusted science that’s helping you get there.
How does it work?
UC-II® helps support your joints’ natural cartilage repair process and encourages the formation of new cartilage.*vi, vii, viii
UC-II® collagen retains its unique triple helix structure, allowing it, when consumed, to activate a targeted immune response in the gut that supports this process.
And it does all this at a conveniently low dose of just 40 mg/day.i, ii, iii, iv, v
UC-II® helps support your joints’ natural cartilage repair process and encourages the formation of new cartilage.*vi, vii, viii
UC-II® collagen retains its unique triple helix structure, allowing it, when consumed, to activate a targeted immune response in the gut that supports this process.
And it does all this at a conveniently low dose of just 40 mg/day.i, ii, iii, iv, v
Take it your way
UC-II® collagen is available from a variety of established brands, so you can choose the best supplement for you.
Your questions,
answered.
What is UC-II® collagen?
UC-II® collagen is a form of type II collagen, which is the main structural protein in cartilage, the tissue that cushions your joints. UC-II® collagen preserves its natural structure and is therefore known as ‘undenatured’ or ‘native’ type II collagen.
How often do I need to take it?
UC-II® collagen is effective at a conveniently low dose, which means you only need to take it once a day.
How do I know if UC-II® collagen is right for me?
If you want to keep doing what you love without being held back by joint discomfort or stiffness, UC-II® collagen is the right ingredient for you. It supports joint flexibility, comfort, and mobility, so you can move with more freedom and more confidence.
What makes UC-II® collagen different from other joint health ingredients?
- Most researched brand of undenatured type II collagen on the market*
- Unique way of working that supports the body’s natural cartilage repair process and promotes the building of new cartilage in the joints**v, vi, vii
- Delivers joint health benefits with just one small daily dose
What are the different types of collagen and where are they found in the body?
More than 20 types of collagen have been identified, but types I, II, and III make up 80–90% of the collagen found in the body.ix But they are all located in different places:x
| Types | Where they are found in the body | Typical dietary sources |
| Type I | Skin, hair, nails, ligaments, bones, organs | Beef, fish |
| Type II | Cartilage (joints), gut tissue | Chicken, beef |
| Type III | Organs, blood vessels, muscles | Beef, fish |
* Animal studies (conducted in rodents) suggest that the likely mechanism of action is that it promotes normal inflammatory response while helping to support cartilage regeneration.
**As of January 2026.
References
- 1
Schön., et al. (2022). UC-II® undenatured type II collagen for knee joint flexibility: A multicenter, randomized, double-blind, placebo-controlled clinical study. J Integr Complement Med, 28 (6), 540–548.
- 2
Soucie, J. M., et al. (2011). Range of motion measurements: reference values and a database for comparison studies. Haemophilia, 17(3), 500- 507.
- 3
Lugo., et al. (2013). Undenatured type II collagen for joint support: A randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr, 10, 48.
- 4
Knaub., et al. (2022). UC-II® undenatured type II collagen reduces knee joint discomfort and improves mobility in healthy subjects: A randomized, double-blind, placebo-controlled clinical study. J Clin Trials. 12(1):1000492.
- 5
Lugo et al. (2016). Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: A multicenter randomized, double-blind, placebo-controlled study. Nutr J, 15, 14.
- 6
Pan, P., et al. (2024). Undenatured type II collagen protects against collagen-induced arthritis by restoring gut-joint homeostasis and immunity. Communications biology, 7(1), 804.
- 7
Bagi., et al. (2017). Oral administration of undenatured native chicken type II collage (UC-II®) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA). Osteoarthritis Cartilage, 25(12), 2080-2090.
- 8
Bagchi, D., et al. (2002). Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. International journal of clinical pharmacology research, 22(3-4), 101–110.
- 9
Lodish et al. (2000). Collagen: The Fibrous Proteins of the Matrix. Molecular Cell Biology 22.3, 4th edition.
- 10
León-López et al. (2019). Hydrolyzed Collagen—Sources and Applications. Molecules, 24(22), 4031.